P. M. Levine, P. Gong, K. L. Shepard, and R. Levicky, “Active CMOS array for electrochemical sensing of biomolecules” IEEE Custom Integrated Circuits Conference, 2007.

We describe the design of a 4Å~4 active sensor array for multiplexed electrochemical biomolecular detection in a 0.25- μm-CMOS process. Integrated potentiostats sense the current flowing through the on-chip Au electrodes that result from reactions occurring at the chip surface. Preliminary experimental results include cyclic voltammetry of several redox species and application to DNA probe coverage characterization.